A Solution to a Single Molecular Experiment Problem
Yanhui Liu 1, Hu Chen 2, Lin Hu 3*, Zhong-Can Ou-Yang 4, Jie Yan 21 Guizhou Provincial Key Lab for Photoelectron Technology and Application, Guizhou University, Guiyang, 550025, China; and National University of Singapore, Department of Physics, 2 Science Drive 3, 117542, Singapore.
2 National University of Singapore, Department of Physics, 2 Science Drive 3, 117542, Singapore.
3 Guizhou Provincial Key Lab for Photoelectron Technology and Application, Guizhou University, Guiyang, 550025, China.
4 Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing, 100080, China.
Received 18 July 2008; Accepted (in revised version) 13 November 2008
Available online 6 February 2009
Recently Hari Shroff and his collaborators [Nano Letters 5 (2005)] developed a nanoscopic force sensor, but the force which they measured in their single molecular experiment was much lower than the theoretical critical value. In order to fix this problem, we investigate the micromechanics of dsDNA based on the worm-like chain model and flexible hinge model by using Monte Carlo algorithm. The simulation results not only address Hari Shroff's experiment difficulty reasonably, but also provide strong support for flexible hinge mechanism put forward recently by Yan and Marko [Phys. Rev. Lett. 93 (2004)].AMS subject classifications: 65Z05, 92-08, 65Y99, 68W99
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Key words: Monte Carlo algorithm, worm-like chain (WLC) model, flexible hinge model, single molecular experiment, micromechanics of double-stranded DNA (dsDNA).
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