Spectral Solutions of a Fractional-Order Mathematical Model for Lung Cancer, Sensitivity Analysis, and Feedback Control

Abstract

A fractional-order mathematical model of lung cancer is used to describe the dynamics of tumor growth and the interactions between cancer cells and immune cells. To obtain approximate solutions and better understand the behavior of the state functions, a pseudo-operational collocation scheme employing shifted Jacobi polynomials as basis functions is introduced. Initially, the existence and uniqueness of solutions to the model are established using the Leray-Schauder fixed-point theorem. Error bounds for the residual functions are estimated within a Jacobi-weighted $L^2$-space. To enhance the accuracy and reliability of the results, two distinct strategies are implemented: sensitivity analysis and feedback control. The feedback control of the proposed pseudo-operational spectral method is performed using the method of Lagrange multipliers, marking its first application in this context. Spectral solutions are derived by applying the pseudo-operational scheme to both the original model and the model with control functions. Improved performance and outputs are anticipated following the application of the feedback control strategy. Finally, comprehensive biological interpretations of the results are provided, offering insights into the practical implications of the model.