We consider the non-cutoff Vlasov-Poisson-Boltzmann (VPB) system of two species with soft potential in the whole space $\mathbb{R}^3$ when an initial data is near Maxwellian. Continuing the work Deng [Comm. Math. Phys. 387 (2021)] for hard potential case, we prove the global regularity of the Cauchy problem to VPB system for the case of soft potential in the whole space for the whole range $0<s<1.$ This completes the smoothing effect of the Vlasov-Poisson-Boltzmann system, which shows that any classical solutions are smooth with respect to $(t,x,v)$ for any positive time $t>0.$ The proof is based on the time-weighted energy method building upon the pseudo-differential calculus.